COVID-19 pandemic caused rapid brain aging in adolescents Adolescents Aging Brain Coronavirus Disease COVID Pandemic Neurology BiologicalPsyc1 Stanford UCSF
By Benedette Cuffari, M.Sc.Dec 4 2022Reviewed by Danielle Ellis, B.Sc. In a recent Biological Psychiatry: Global Open Science study, Stanford University researchers assess how stress and social disruptions caused by the coronavirus disease 2019 pandemic have affected the neurological development of young adults.
Throughout the COVID-19 pandemic, increased social isolation and the transition to almost entirely remote learning settings has led many young adults and children to experience significant adversities. These new challenges are coupled with increased financial stress, exposure to familial violence, and the potential adverse effects of infection with the severe acute respiratory syndrome coronavirus 2 , the agent responsible for COVID-19.
In addition to self-reported mental health symptoms, a subset of the study cohort also provided magnetic resonance imaging scans of their brains to obtain cortical thickness and subcortical measurements. These values were used to calculate brain age gap estimate values for all study participants through the use of a sex-specific machine-learning-based model developed by the ENIGMA-Brain Age working group.
Analysis of the MRI scans demonstrated that peri-COVID group participants had reduced bilateral cortical thickness, as well as greater bilateral hippocampal and amygdala volumes. Furthermore, the peri-COVID group was found to have a greater BrainAGE as compared to those in the pre-COVID group.
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