Heart disease patients with symptomatic COVID-19 are often treated with nirmatrelvir-ritonavir (Paxlovid) to prevent progression to severe disease; however, it can interact with some previously prescribed medications. A review paper published today in the Journal of the American College of Cardiology examines the potential drug-drug interactions (DDIs) between Paxlovid and commonly used cardiovascular medications, as well as potential options to mitigate severe adverse effects.
Heart disease patients with symptomatic COVID-19 are often treated with nirmatrelvir-ritonavir to prevent progression to severe disease; however, it can interact with some previously prescribed medications. A review paper published today in theexamines the potential drug-drug interactions between Paxlovid and commonly used cardiovascular medications, as well as potential options to mitigate severe adverse effects.
"The prescription of Paxlovid could be incorporated into an order set, which allows physicians, whether it beor cardiology providers, to consciously rule out any contraindications to the co-administration of Paxlovid. Consultation with other members of the health care team, particularly pharmacists, can prove to be extremely valuable. However, a health care provider's fundamental understanding of the drug-drug interactions withPaxlovid received emergency use authorization from the U.S.
Dr. Ganatra discusses the potential drug-drug interactions between Paxlovid and commonly used cardiovascular medications. Credit: American College of Cardiology
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