Comparative immunogenicity of COVID-19 vaccines in North California medrxivpreprint UofCalifornia COVID19 SARSCoV2 Immunogenicity
By Pooja Toshniwal PahariaOct 4 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers evaluated vaccine responses among North Californian residents, including differences in vaccine side effects and antibody titers by age, sex, and vaccine type. They also evaluated the responses among individuals with comorbidities that enhance severe coronavirus disease 2019 risks.
The study was conducted between July 2020 and March 2021 and comprised 5,500 adult individuals from the Eastern Bay area of Northern California. Data were obtained via comprehensive questionnaires, and biological samples were obtained for anti-SARS-CoV-2 Ab testing. The study exposures comprised Johnson & Johnson , Pfizer-BioNTech , and Moderna COVID-19 vaccines.
Results Related StoriesAt T1, 2,049 individuals had received ≥1 vaccination. They had reported their S/C ratio, of which only one participant had received J & J vaccination, and therefore, 2,048 individuals who received Moderna or Pfizer-BioNTech vaccines were analyzed. Among 12 cities in the East Bay region, high vaccination rates with consistent vaccination coverage across postal codes were observed, with the median rate of COVID-19 vaccination being 99%.
Fully vaccinated Moderna vaccinees had greater odds of reporting fatigue, body ache, abdominal pain, fever, chills, nausea, headache, pain, and erythema at the site of injection and a higher count of side effects. Among single-dose J & J vaccinees and two-dose Pfizer-BioNTech vaccinees, J & J vaccinees had greater odds of reporting fever, chills, body ache, headache, and the total number of side effects but lesser odds of erythema and pain at the site of injection.
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