Fresh discoveries about a certain type of immune cell could give lung cancer patients a more accurate prognosis and better identify who will benefit from immunotherapies.
Researchers have found that the location in and around tumors of cytotoxic T cells, which play a key role in fighting cancer, may help predictand indicate whether or not treatments will work. The findings could help to pave the way for improved immunotherapies—powerful but expensive life-extending treatments that currently fail in 80% of cases—allowing them to work more effectively in more patients, researchers say.
T cells have an in-built safety mechanism designed to stop them from becoming overactive when fighting an infection. By raising the levels of these enzymes, tumors exploit this and escape destruction. High levels of CD39 on the surface of another type of T cell, known as regulatory T cells, which normally prevent the immune system from becoming overactive, were associated with reduced survival.
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