Low birthweight independently linked to increased risk of type 2 diabetes, including lower age at diagnosis
). Moreover, the findings that the participants with type 2 diabetes with birthweight 3700 g more frequently reported a family history of type 2 diabetes, further support the conclusion that enrichment for genetic variants associated with type 2 diabetes is unlikely to explain the differential characteristics observed.
Strengths of this study include a large well-characterised cohort of individuals recently diagnosed with type 2 diabetes, with more than 50% recruited from Denmark’s primary healthcare sector. Birthweights were ascertained from digitised original midwife records.
Limitations include the cross-sectional study design, which has an inherent risk of sampling bias and precludes causal inferences and the exploration of temporal relationships. However, participant inclusion was nationwide and included only those with new-onset type 2 diabetes from both general practice and hospital clinics.
Danmark Seneste Nyt, Danmark Overskrifter
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