Bioactive compounds derived from Ganoderma lucidum exhibit anti-SARS-CoV-2 activity SARSCoV2 Coronavirus Disease COVID Ganoderma lucidum triterpenoids Omicron
Study: Lucidenic acid A inhibits the binding of hACE2 receptor with spike protein to prevent SARS-CoV-2 invasion. Image Credit: sritakoset / Shutterstock
Ganoderma lucidum is a widely-used Chinese medicinal fungus belonging to the Polyporaceae family. Bioactive compounds isolated from this fungus have shown potent immune-enhancing and antiviral activities. A network model of potential antiviral target genes of Ganoderma lucidum was created, which included the targets related to inflammation, infection, cancer, and other pathways. Based on the activities of identified targets, scientists hypothesized that the bioactive compounds could be used to treat SARS-CoV-2 infection.
Lucidenic acid A was found to interact with human ACE2 by forming a hydrogen bond, which subsequently prevented the interaction between viral spike protein and ACE2. Overall, these observations indicate that lucidenic acid A can strongly inhibit the host cell entry of wild-type SARS-CoV-2 and its variants.
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