Photo submitted by the folks at Bandon Bicycle Works, “Cape Blanco, Oregon, on a beautiful Black Mountain Cycles Monstercross.” We always love seeing photos from where you are riding and are happy to share them with our readers around the world here on the Pic Of The Day. Send in your pics with a description here.
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Bikerumor Pic Of The Day: Northern Italy Gravel RidePhoto submitted by Ronny Ansaldi from last December, “Amazing gravel ride on snowy roads in northern Italy’s countryside. The best way to spend a beautiful sunny day with my wife.” We always love seeing photos from where you are riding and are happy to share them with our readers around the world here on the Pic
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Bikerumor Pic Of The Day: Grand Coulee Dam, WashingtonPhoto submitted by Lee Sorensen, “On the way to Grand Coulee Dam (eastern WA.)” We always love seeing photos from where you are riding and are happy to share them with our readers around the world here on the Pic Of The Day. Send in your pics with a description here.
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Tourist drowns after being dragged out to sea by freak wave while taking picA TOURIST has drowned after she was dragged out to the sea by a massive wave while trying to take a picture on the Italian coast. Ines Gomila, 36, was with her husband Sebastian Queiroz, 52, when t…
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Brain teaser challenges you to find missing object in pic in just 11 secondsCAN you crack this viral brain teaser that challenges you to find missing objects in the picture in just 11 seconds? Readers are given a picture of a book shelf with items on it from vases to elves…
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Phase IIb Randomized, Placebo-Controlled, Dose-Escalating, Double-Blind Study of Cannabidiol Oil for the Relief of Symptoms in Advanced Cancer (MedCan1-CBD) | Journal of Clinical OncologyPURPOSE To determine whether cannabidiol (CBD) oil can improve symptom distress in patients with advanced cancer receiving palliative care. METHODS Participants were adults with advanced cancer and symptom distress (Edmonton Symptom Assessment Scale [ESAS] total score of ≥ 10/90) who received titrated CBD oil 100 mg/mL, 0.5 mL once daily to 2 mL three times a day, or matched placebo for 28 days. The primary outcome was ESAS total symptom distress score (TSDS) at day 14. Response was defined as a decrease in TSDS by ≥ 6 at day 14. Secondary outcomes were ESAS TSDS over time, individual symptom scores, patient-determined effective dose, opioid use, Global Impression of Change, depression, anxiety, quality of life, and adverse events. RESULTS Of the 144 patients randomly assigned, the planned sample size of 58 participants on CBD and 63 on placebo reached the primary analysis point (day 14). The unadjusted change in TSDS from baseline to day 14 was –6.2 (standard deviation, 14.5) for placebo and –3.0 (standard deviation, 15.2) for CBD with no significant difference between arms (P=.24). Similarly, there was no detected difference in proportion of responders (placebo: 37 of 63 [58.7%], CBD: 26 of 58 [44.8%], P=.13). All components of ESAS improved (fell) over time with no difference between arms. The median dose of participant-selected CBD was 400 mg per day with no correlation with opioid dose. There was no detectable effect of CBD on quality of life, depression, or anxiety. Adverse events did not differ significantly between arms apart from dyspnea that was more common with CBD. Most participants reported feeling better or much better at days 14 (53% CBD and 65% placebo) and 28 (70% CBD and 64% placebo). CONCLUSION CBD oil did not add value to the reduction in symptom distress provided by specialist palliative care alone.
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Schools in Powys 'won't go on a four day week to save money' - councilSchools in Powys will not move to a four-day week to reduce running costs, the county council has confirmed.
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