A study published in BMCNutr reports an association between vitamin D deficiency and insulin resistance in Indian adolescents.
]. Several studies have been conducted to evaluate the ability of TyG index to predict IR. A study found a concordance of 0.91 between the TyG index and the Hyperinsulinemic-euglycemic clamp , indicating a strong synergy between the two tests []. Similar results were found in another study which showed that the TyG index diagnosed IR with a sensitivity of 95.6 and specificity of 79.9, and the study also reported that the TyG index had better predictive power than the HOMA-IR index [].
We observed two research gaps while doing the literature review: first, no study has examined the association between vitamin D and IR in Indian adolescents on national level. Second, most of the studies in this context have used the HOMA-IR, Matsuda index, Insulin sensitivity index , or the Hyperinsulinemic-euglycemic clamp to assess IR; which implies that the association between vitamin D and TyG index has not been explored well enough.
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