Arms hands board seats to Intel and Qualcomm alumni ahead of IPO
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AWS follows AMD and Intel down the specialized chips pathCPU roadmaps are fragmenting to serve a variety of needs. Time to do some homework
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Lorraine viewers up in arms over reporter’s World Cup wardrobe faux pasLORRAINE viewers were left up in arms over a reporter’s World Cup wardrobe faux pas today. It came as England get set to play Wales in today’s World Cup match. The reporter in question popped up on…
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First look inside Calverely Arms after stunning 'five week' renovation projectThe Calverley Arms is relaunching and opening its doors to guests on Friday 2 December following a major transformation.
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How will America deal with three-way nuclear deterrence?It risks a new arms race, not only against Russia but also against China
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Spice Girl Geri Horner accused of disrupting phone signalsNeighbours are up in arms about the barn she built to house 14 horses
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Phase IIb Randomized, Placebo-Controlled, Dose-Escalating, Double-Blind Study of Cannabidiol Oil for the Relief of Symptoms in Advanced Cancer (MedCan1-CBD) | Journal of Clinical OncologyPURPOSE To determine whether cannabidiol (CBD) oil can improve symptom distress in patients with advanced cancer receiving palliative care. METHODS Participants were adults with advanced cancer and symptom distress (Edmonton Symptom Assessment Scale [ESAS] total score of ≥ 10/90) who received titrated CBD oil 100 mg/mL, 0.5 mL once daily to 2 mL three times a day, or matched placebo for 28 days. The primary outcome was ESAS total symptom distress score (TSDS) at day 14. Response was defined as a decrease in TSDS by ≥ 6 at day 14. Secondary outcomes were ESAS TSDS over time, individual symptom scores, patient-determined effective dose, opioid use, Global Impression of Change, depression, anxiety, quality of life, and adverse events. RESULTS Of the 144 patients randomly assigned, the planned sample size of 58 participants on CBD and 63 on placebo reached the primary analysis point (day 14). The unadjusted change in TSDS from baseline to day 14 was –6.2 (standard deviation, 14.5) for placebo and –3.0 (standard deviation, 15.2) for CBD with no significant difference between arms (P=.24). Similarly, there was no detected difference in proportion of responders (placebo: 37 of 63 [58.7%], CBD: 26 of 58 [44.8%], P=.13). All components of ESAS improved (fell) over time with no difference between arms. The median dose of participant-selected CBD was 400 mg per day with no correlation with opioid dose. There was no detectable effect of CBD on quality of life, depression, or anxiety. Adverse events did not differ significantly between arms apart from dyspnea that was more common with CBD. Most participants reported feeling better or much better at days 14 (53% CBD and 65% placebo) and 28 (70% CBD and 64% placebo). CONCLUSION CBD oil did not add value to the reduction in symptom distress provided by specialist palliative care alone.
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