Adaptive immune responses in adults of various ages receiving 2 doses of the BNT162b2 mRNA vaccine NaturePortfolio UniHannover vaccine vaccination immune immunity mRNA COVID19 coronavirus covid
By Bhavana KunkalikarOct 21 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in Nature Aging, researchers assessed the correlation between immunosenescence and poor coronavirus disease 2019 vaccination outcomes in older adults.
About the study In the present study, researchers assessed the adaptive immunological reactions of persons aged between 22 and 99 who received two doses of the BNT162b2 mRNA vaccination. Taking into account the surface expression of the C-C chemokine receptor type 7 and CD45RA, the team classified the CD4+ and CD8+ T cells into four differentiation subsets naive, central memory T , effector memory T , and effector memory CD45RA+ T . The proportions of the cells were associated with the frequency of S-specific T cells, as determined by IFN-ELISpot.
As a result of Spike peptide stimulation, there was also an age-dependent decline in CD4+ T cells that produced interleukin -2+IFN-ɣ+, TNF-⍺+ IFN-ɣ+, and IL-2+ TNF-⍺+, with older people exhibiting a striking decline in these polyfunctional T cells in comparison to the two younger age groups.
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